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Items: 4

1.

Globally reduced N6-methyladenosine (m6A) in C9ORF72-ALS/FTD dysregulates RNA metabolism and contributes to neurodegeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL24676
56 Samples
Download data: NARROWPEAK, TXT
Series
Accession:
GSE203581
ID:
200203581

PubMed Full text in PMC Similar studies

2.

N6-methyladenosine regulates RNA metabolism and neurodegeneration in C9ORF72-ALS/FTD [seq_polyA_RNA-RIP]

(Submitter supplied) N6-methyladenosine (m6A) is the most prevalent internal mRNA modification and regulates RNA metabolism. Repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Here, we showed that m6A is downregulated in C9ORF72-ALS/FTD patient-derived iPSC-differentiated neurons and postmortem brain tissues. The global m6A hypomethylation leads to transcriptome-wide mRNA stabilization and upregulated gene expression, especially ones involved in synaptic activity and neuronal functions. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platform:
GPL24676
10 Samples
Download data: TXT
Series
Accession:
GSE203578
ID:
200203578

PubMed Full text in PMC Similar studies Analyze with GEO2R

3.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:
Homo sapiens
16826 Series
928378 Samples
Download data
Platform
Accession:
GPL24676
ID:
100024676

4.

iPSN-Ctrl-3_IP_YTHDF2-RIP

Organism:
Homo sapiens
Source name:
iPSC-derived neuron
Platform:
GPL24676
Series:
GSE203578 GSE203581
Download data: TXT
Sample
Accession:
GSM6176470
ID:
306176470

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db=gds|term=GSM6176470[Accession]|query=46|qty=2|blobid=MCID_671f8ef0e158b40557c2706a|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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