GSM6248679[Accession] - GEO DataSets

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Items: 4

Select item 2002062491.

Separation of transcriptional repressor and activator functions in HDAC3

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL19132 GPL22106
28 Samples

Download data: BED, BIGWIG

Series

Accession:: GSE206249

ID:: 200206249

PubMed Full text in PMC Similar studies

Select item 2002062472.

Separation of transcriptional repressor and activator functions in HDAC3 [RNA-Seq]

(Submitter supplied) The histone deacetylase HDAC3 is associated with the NCoR/SMRT co-repressor complex and its canonical function is in transcriptional repression, but it can also activate transcription. Here we show that the repressor and activator functions of HDAC3 can be genetically separated in Drosophila. A lysine substitution in the N-terminus (K26A) disrupts its catalytic activity and activator function, whereas a combination of substitutions (HEBI) abrogating the interaction with SMRTER enhance repressor activity beyond wild-type in the early embryo. more...