GSM6252867[Accession] - GEO DataSets

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Items: 4

Select item 2002063871.

YTHDF2 inhibition potentiates radiotherapy by reprogramming suppressive myeloid cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21103 GPL24247
46 Samples

Download data: MTX, NARROWPEAK, TSV, TXT

Series

Accession:: GSE206387

ID:: 200206387

PubMed Similar studies

Select item 2002063842.

YTHDF2 inhibition potentiates radiotherapy by reprogramming suppressive myeloid cells [MeRIP-Seq]

(Submitter supplied) RNA N6-methyladenosine (m6A) modification is implicated in cancer progression. However, the impact of m6A on the antitumor effects of radiotherapy and the related mechanisms are unknown. Here we show that ionizing radiation (IR) induces immunosuppressive myeloid-derived suppressor cell (MDSC) expansion and YTHDF2 expression in both murine models and humans. Following IR, loss of Ythdf2 in myeloid cells augments antitumor immunity and overcomes tumor radioresistance by altering MDSC differentiation and inhibiting MDSC infiltration and suppressive function. more...