GSM6689143[Accession] - GEO DataSets

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Items: 4

Select item 2002167051.

Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus; Mus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL24676 GPL6246
46 Samples

Download data: CEL, H5

Series

Accession:: GSE216705

ID:: 200216705

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002167012.

Loss of evolutionary conserved GM-CSF-dependent signature in pulmonary macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment (microarray)

(Submitter supplied) Alveolar GM-CSF is required for monocytes to differentiate into alveolar macrophages (AM) that control alveolar homeostasis and dampen inflammation. By mapping cross-species AM development stages to clinical lung samples, we discovered that COVID-19 is marked by defective GM-CSF-dependent AM instruction and accumulation of proinflammatory macrophages. In a multi-center, open-label, randomized, controlled trial in 81 non-ventilated COVID-19 patients with respiratory failure, we found that inhalation of rhu-GM-CSF did not improve mean oxygenation parameters compared with standard treatment. more...

Organism:: Mus; Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
27 Samples

Download data: CEL, TXT

Series

Accession:: GSE216701

ID:: 200216701

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000062463.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site