GSM687915[Accession] - GEO DataSets

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Items: 3

Select item 2000278631.

Genome wide analysis of Histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene

(Submitter supplied) Epigenetic deregulation plays a critical role in the pathogenesis of Acute Myeloid Leukemia. But changes in histone modification patterns at the epigenome level still remain largely unknown. Here, we analyzed alterations of histone H3 acetylation patterns in a large number of patients with AML compared to CD34+ progenitor cells. Using ChIP-Chip assays, we demonstrate that AML blasts exhibit significant changes in Histone H3 acetylation levels at more than 1000 genomic loci. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by array

Platform:: GPL10087
105 Samples

Download data: GPR

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Accession:: GSE27863

ID:: 200027863

Select item 1000100872.

UniMuenster-HomoSapiens-30K-Promoter_v1

(Submitter supplied) Human putative promoter sequences of all known genes and sca/miRNA genes were downloaded from UCSC Golden Path Database based on NCBI Build 35. The putative promoter sequences were defined as 2,000 bases upstream and 1,000 bases downstream from transcription start site. Sequences were repeat-masked. Probes were designed from the sense strand of the non-repeat-masked portions of the promoter regions, with these probe restrictions: 1) Length: 46 – 55 bases 2) Tm: 69 – 79 °C 3) Creatable by NimbleGen in 148-rounds of A, C, G, T. more...