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Items: 4

1.

Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications [ChIP-seq]

(Submitter supplied) Background: DNA hypermethylation at promoter CpG islands (CGIs) is a hallmark of cancers and could lead to dysregulation of gene expression in the development of cancers, however, its dynamics and regulatory mechanisms remain elusive. Bivalent genes, that direct development and differentiation of stem cells, are found to be frequent targets of hypermethylation in cancers. Results: Here we performed comprehensive analysis across multiple cancer types and identified that the decrease in H3K4me1 levels coincides with DNA hypermethylation at the bivalent promoter CGIs during tumorigenesis. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL16791
18 Samples
Download data: BW
Series
Accession:
GSE222523
ID:
200222523

PubMed Full text in PMC Similar studies

2.

Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications

(Submitter supplied) Background: DNA hypermethylation at promoter CpG islands (CGIs) is a hallmark of cancers and could lead to dysregulation of gene expression in the development of cancers, however, its dynamics and regulatory mechanisms remain elusive. Bivalent genes, that direct development and differentiation of stem cells, are found to be frequent targets of hypermethylation in cancers. Results: Here we performed comprehensive analysis across multiple cancer types and identified that the decrease in H3K4me1 levels coincides with DNA hypermethylation at the bivalent promoter CGIs during tumorigenesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing
Platform:
GPL16791
28 Samples
Download data: BW, COV
Series
Accession:
GSE222612
ID:
200222612

PubMed Full text in PMC Similar studies

3.

Illumina HiSeq 2500 (Homo sapiens)

Organism:
Homo sapiens
12139 Series
348714 Samples
Download data
Platform
Accession:
GPL16791
ID:
100016791

4.

LSD1_HCT116_KO_H3K4me1_rep2

Organism:
Homo sapiens
Source name:
HCT116
Platform:
GPL16791
Series:
GSE222523 GSE222612
Download data: BW
Sample
Accession:
GSM6925414
ID:
306925414

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db=gds|term=GSM6925414[Accession]|query=5|qty=2|blobid=MCID_67097b51475a635e85abf0ee|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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