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Items: 4

1.

Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Novel Role in Autophagy

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL6246 GPL9185
8 Samples
Download data: CEL, TXT
Series
Accession:
GSE28084
ID:
200028084
2.

Expression data from CH/LE Mice

(Submitter supplied) We are using genome-wide ChIP-seq with isoform-specific antibodies and chromatin from select tissues of mice challenged with different dietary conditions that enrich for specific SREBPs. We show that hepatic SREBP-2 binds preferentially to two different gene-proximal motifs as well as SREBP-2 directly activates autophagy genes during cell sterol depletion, conditions known to induce both autophagy and nuclear SREBP-2 levels.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE28083
ID:
200028083
3.

[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site
Organism:
Mus musculus
143 DataSets
2496 Series
28 Related Platforms
30138 Samples
Download data
Platform
Accession:
GPL6246
ID:
100006246
4.

LE biological rep3

Organism:
Mus musculus
Source name:
lovastatin/ezetimibe fed
Platform:
GPL6246
Series:
GSE28083 GSE28084
Download data: CEL
Sample
Accession:
GSM694321
ID:
300694321
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Supplemental Content

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