GSM7036364[Accession] - GEO DataSets

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Items: 4

Select item 2002249711.

Analysis of alternative exon-dependent interactome remodelling reveals multitasking functions of gene regulatory factors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL24247
56 Samples

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Accession:: GSE224971

ID:: 200224971

PubMed Similar studies

Select item 2002249692.

Analysis of alternative exon-dependent interactome remodelling reveals multitasking functions of gene regulatory factors (Chtop RNA-Seq)

(Submitter supplied) Alternative splicing is fundamental for the expansion of biological complexity, particularly in the vertebrate nervous system. Increasing evidence indicates that developmental stage and tissue-dependent alternative exons often control protein-protein interactions, yet only a minor fraction of these events has been characterized at the protein level. Using affinity purification-mass spectrometry (AP-MS) we show that approximately 60% of analyzed neural-differential exons in proteins previously implicated in transcriptional regulation result in the gain or loss of interaction partners. more...