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Items: 3

1.

Characterizing glucokinase variant mechanisms using a multiplexed abundance assay

(Submitter supplied) Amino acid substitutions can perturb protein activity in multiple ways. Understanding their mechanistic basis may pinpoint how residues contribute to protein function. Here, we characterize the mechanisms of human glucokinase (GCK) variants, building on our previous comprehensive study on GCK variant activity. We assayed the abundance of 95\% GCK missense and nonsense variants, and found that 59\% of hypoactive variants have a decreased cellular abundance. more...
Organism:
synthetic construct
Type:
Other
Platform:
GPL27609
112 Samples
Download data: CSV, TXT
Series
Accession:
GSE226732
ID:
200226732

PubMed Full text in PMC Similar studies

2.

NextSeq 550 (synthetic construct)

Organism:
synthetic construct
28 Series
593 Samples
Download data
Platform
Accession:
GPL27609
ID:
100027609

3.

nonselect_library_replicate1_tile14 (70)

Organism:
synthetic construct
Source name:
Yeast cells
Platform:
GPL27609
Series:
GSE226732
Download data
Sample
Accession:
GSM7082761
ID:
307082761

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db=gds|term=GSM7082761[Accession]|query=22|qty=2|blobid=MCID_6731f4bf4322b4744261a692|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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