GSM7152157[Accession] - GEO DataSets

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Items: 4

Select item 2002290811.

Reactivation of memory-encoding dentate gyrus neurons during memory consolidation is associated with subregion-specific, learning- and sleep-mediated biosynthetic changes [spatial protein expression level]

(Submitter supplied) Post-learning sleep plays an important role in hippocampal memory processing, including contextual fear memory (CFM) consolidation. Here, we used targeted recombination in activated populations (TRAP) to label context-encoding engram neurons in the hippocampal dentate gyrus (DG) and assessed reactivation of these neurons during post-learning sleep. We find that post-learning sleep deprivation (SD), which impairs CFM consolidation, selectively disrupts reactivation in inferior blade DG engram neurons. more...

Organism:: blank sample; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL29487 GPL24247
123 Samples

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Accession:: GSE229081

ID:: 200229081

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Select item 2002290822.

Reactivation of memory-encoding dentate gyrus neurons during memory consolidation is associated with subregion-specific, learning- and sleep-mediated biosynthetic changes.

(Submitter supplied) This superseries contain NanoString GeoMx spatial profiling datasets that measured RNA and protein expression levels from ROIs of mice that received fear-conditioning and/or sleep deprivation. ROIs were collected from both hemispheres of the brain, including 5 different subregions of the hippocampus (CA1, CA3, DG-superior blade, DG-inferior blade, and DG-hilus).