GSM7273481[Accession] - GEO DataSets

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Items: 4

Select item 2002314061.

IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21493 GPL19057 GPL13112
72 Samples

Download data: COV, MTX, TAB, TSV, TXT

Series

Accession:: GSE231406

ID:: 200231406

PubMed Full text in PMC Similar studies

Select item 2002314012.

Genome-wide open chromatin status in WT and IRF8KO microglia [ATAC-seq]

(Submitter supplied) The role of the lineage-determining transcription factor, Interferon regulatory factor (IRF8), in microglia remains unelucidated. We report the genome-wide chromatin status in adult wild-type (WT) and IRF8-knockout (IRF8KO) microglia by ATAC-Seq. Deep-sequencing and subsequent differential analysis revealed that chromatin accessibility in microglia requires IRF8. At the same time, the loss of IRF8 gains aberrant chromatin accessibility that potentially confers mRNA transcription of the genes upregulated in IRF8KO microglia. more...