GSM7273534[Accession] - GEO DataSets

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Items: 4

Select item 2002314061.

IRF8 defines the epigenetic landscape in postnatal microglia, thereby directing their transcriptome programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL21493 GPL19057 GPL13112
72 Samples

Download data: COV, MTX, TAB, TSV, TXT

Series

Accession:: GSE231406

ID:: 200231406

PubMed Full text in PMC Similar studies

Select item 2002314032.

Transcriptome profiles of wild-type, IRF8KO, IRF8cKO, Batf3KO, 5xFAD, and 5xFAD/IRF8KO microglia [RNA-seq]

(Submitter supplied) The role of the lineage-determining transcription factor IRF8 in microglia remains unelucidated. We report the genome-wide, transcriptome profiles of wild-type, IRF8KO, IRF8cKO, Batf3KO, 5xFAD, and 5xFAD/IRF8KO microglia. Deep-sequencing and subsequent differential analysis revealed the impacts of IRF8 on microglia-specific transcription programs, such as cell identity. Sall1 and Batf3 genes were identified as a downstream transcription factor of IRF8, and Batf3 dependent genes showed correlation with IRF8-dependent genes in microglia. more...