GSM7304288[Accession] - GEO DataSets

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Items: 4

Select item 2002320781.

In vitro reconstitution of epigenetic reprogramming in the human germ line

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL24676 GPL18573
119 Samples

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Series

Accession:: GSE232078

ID:: 200232078

PubMed Full text in PMC Similar studies

Select item 2002318132.

In vitro reconstitution of epigenetic reprogramming in the human germ line [EM-Seq]

(Submitter supplied) Epigenetic reprogramming resets parental epigenetic memories and differentiates primordial germ cells (PGCs) into mitotic pro-spermatogonia or oogonia, ensuring sexually dimorphic germ-cell development for totipotency. However, the mechanism of epigenetic reprogramming in humans remains unknown. Here, we establish a robust strategy for inducing epigenetic reprogramming and differentiation of pluripotent stem cell (PSC)-derived human PGC-like cells (hPGCLCs) into mitotic pro-spermatogonia or oogonia, coupled with their extensive amplification (~>10(10)-fold). more...