GSM740350[Accession] - GEO DataSets

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Items: 4

Select item 2000299021.

Mesothelioma tumor aCGH profiles

(Submitter supplied) Malignant pleural mesotheliomas (MPMs) often show CDKN2A and NF2 inactivation but other highly recurrent mutations have not been described. To identify additional driver genes, we used an integrated genomic analysis of 53 MPM tumor samples to guide a focused sequencing effort that uncovered somatic inactivating mutations in BAP1 in 23% of MPM. The BAP1 nuclear deubiquitinase is known to target histones (together with ASXL1 as a Polycomb repressor subunit) and the HCF1 transcriptional co-factor, and we show that BAP1 knockdown in MPM cell lines affects E2F and Polycomb target genes. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL9128
53 Samples

Download data: PDF, TXT

Series

Accession:: GSE29902

ID:: 200029902

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000292112.

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array; Genome variation profiling by genome tiling array

Platforms:: GPL96 GPL9128 GPL3718
131 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE29211

ID:: 200029211

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000091283.

Agilent-014693 Human Genome CGH Microarray 244A (Probe name version)

(Submitter supplied) This microarray is Agilent’s premium product for human DNA copy-number profiling. Over 236,000 60-mer oligonucleotide probes, specifically optimized for copy-number measurement, span coding and non-coding genomic sequences with median spacing of 7.4 kb and 16.5 kb respectively. This microarray is designed for use with Agilent’s optimized assay protocols, enabling researchers to use nanogram levels of total genomic DNA without complexity reduction. more...