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Items: 4

1.

Double-stranded RNA triggers a distinct integrated stress response in the early embryo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
24 Samples
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Series
Accession:
GSE234230
ID:
200234230

2.

Double-stranded RNA triggers a distinct integrated stress response in the early embryo [cas9 tol2]

(Submitter supplied) Gene functional study and the emerging mRNA therapy technology heavily rely on in vitro transcribed (IVT) mRNA, but the double-stranded RNA (dsRNA) by-product generated during IVT is often recognized by cells as a marker of virus replication, leading to the integrated stress response (ISR).The biological effects of dsRNA in undifferentiated cells differ significantly from those of differentiated counterparts.Here, we found that dsRNA triggered an unprecedented ISR in zebrafish early embryos, leading to developmental delay, severe cell necrosis, and lethal malformations.Mechanistically, dsRNA stimulation caused a PKR-eIF2α independent global translation inhibition and a burst of p53 signaling. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL14875
12 Samples
Download data: XLS, XLSX
Series
Accession:
GSE234227
ID:
200234227

3.

Illumina HiSeq 2000 (Danio rerio)

Organism:
Danio rerio
295 Series
4648 Samples
Download data
Platform
Accession:
GPL14875
ID:
100014875

4.

uninj-5hpf-2

Organism:
Danio rerio
Source name:
whole embryo
Platform:
GPL14875
Series:
GSE234227 GSE234230
Download data
Sample
Accession:
GSM7457624
ID:
307457624

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db=gds|term=GSM7457624[Accession]|query=4|qty=2|blobid=MCID_669e0d2357bd0c1190aacfc8|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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