GSM7549808[Accession] - GEO DataSets

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Items: 4

Select item 2002365531.

CDK12 prevents MYC-induced transcription-replication conflicts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24676 GPL18573 GPL11154
48 Samples

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Accession:: GSE236553

ID:: 200236553

PubMed Full text in PMC Similar studies

Select item 2002365502.

CDK12 prevents MYC-induced transcription-replication conflicts [EdU-seq]

(Submitter supplied) In order to identify genes and pathways necessary to preserve genome integrity upon Myc over-expression, we conducted a large siRNA-based screen in isogenic lines. We discovered several genes that suppressed the Myc-induced DNA-damage response and that were essential for the cell survival upon Myc activation. We idntified CDK12, a cyclin dependent kinase involved in transcriptional control and genome stability. more...