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Items: 3

1.

A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

(Submitter supplied) BCL6 is crucial for B-cell activation and lymphomagenesis. We used integrative genomics to explore BCL6 mechanism in normal and malignant B-cells. Surprisingly, BCL6 assembled distinct complexes at enhancers vs. promoters. At enhancers BCL6 preferentially recruited SMRT, which mediated H3K27 deacetylation through HDAC3, antagonized p300 activity and repressed transcription, but without decommissioning enhancers. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL15433 GPL10999
46 Samples
Download data: BED, BW, TXT, WIG
2.

Illumina Genome Analyzer IIx (Homo sapiens)

Platform
Accession:
GPL10999
ID:
100010999
3.

OCI-LY1_H3K79me2_INPUT

Organism:
Homo sapiens
Source name:
Human DLBCL cell line
Platform:
GPL10999
Series:
GSE29282
Download data: WIG
Sample
Accession:
GSM763413
ID:
300763413
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db=gds|term=GSM763413[Accession]|query=1|qty=2|blobid=MCID_669d0e6857bd0c11909c0290|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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