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Items: 3

1.

RNA polymerase stalling-derived genome instability underlies ribosomal antibiotic efficacy and resistance evolution

(Submitter supplied) Bacteria often evolve antibiotic resistance through mutagenesis. However, the processes causing the mutagenesis have not been fully resolved. Here we found that a broad range of ribosome-targeting antibiotics caused mutations through an underexplored pathway. Focusing on the clinically important aminoglycoside gentamicin, we found that the translation inhibitor caused genome-wide premature stalling of RNA polymerase (RNAP) in a loci-dependent manner. more...
Organism:
Escherichia coli BW25113
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27123
24 Samples
Download data: CSV, XLSX
Series
Accession:
GSE240474
ID:
200240474

PubMed Full text in PMC Similar studies

2.

Illumina NovaSeq 6000 (Escherichia coli BW25113)

Organism:
Escherichia coli BW25113
6 Series
168 Samples
Download data
Platform
Accession:
GPL27123
ID:
100027123

3.

Gentamicin, 60 min, 3'-end-seq, wildtype

Organism:
Escherichia coli BW25113
Source name:
BW25113
Platform:
GPL27123
Series:
GSE240474
Download data
Sample
Accession:
GSM7698582
ID:
307698582

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db=gds|term=GSM7698582[Accession]|query=6|qty=2|blobid=MCID_6739c037c6023e543c342512|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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