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Items: 4

1.

Genomic context sensitizes regulatory elements to genetic disruption

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; synthetic construct
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
Platforms:
GPL27609 GPL21626
154 Samples
Download data: BW, TXT
Series
Accession:
GSE241708
ID:
200241708

PubMed Similar studies

2.

Genomic context sensitizes regulatory elements to genetic disruption [DNA]

(Submitter supplied) Enhancer function is frequently investigated piecemeal using truncated reporter assays or single deletion analysis, thus it remains unclear to what extent their function is influenced by surrounding genomic context. Using our Big-IN technology for targeted integration of large DNAs, we analyzed the regulatory architecture of the Igf2/H19 locus, a paradigmatic model of enhancer selectivity. We assembled payloads containing a 157-kb functional Igf2/H19 locus and engineered mutations to genetically direct CTCF occupancy at the imprinting control region (ICR) that switches the target gene of the H19 enhancer cluster. more...
Organism:
Mus musculus; synthetic construct
Type:
Other
Platforms:
GPL21626 GPL27609
141 Samples
Download data: BW
Series
Accession:
GSE241706
ID:
200241706

PubMed Similar studies

3.

NextSeq 550 (synthetic construct)

Organism:
synthetic construct
28 Series
593 Samples
Download data
Platform
Accession:
GPL27609
ID:
100027609

4.

BAC-Igf2_Igf2_inverted~dCTCFinICR-BS14102A

Organism:
synthetic construct
Source name:
BAC clone library
Platform:
GPL27609
Series:
GSE241706 GSE241708
Download data: BW
Sample
Accession:
GSM7734088
ID:
307734088

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db=gds|term=GSM7734088[Accession]|query=19|qty=3|blobid=MCID_6733e2a83ec0a11b447e5387|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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