GSM7771414[Accession] - GEO DataSets

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Items: 4

Select item 2002532021.

Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Methylation profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL31950 GPL32159
75 Samples

Download data: BED, BW, IDAT

Series

Accession:: GSE253202

ID:: 200253202

Select item 2002428162.

Altered DNA methylation underlies monocyte dysregulation and immune exhaustion memory in sepsis [Array]

(Submitter supplied) Innate immune memory is the process by which pathogen exposure elicits cell-intrinsic states to alter the strength of future immune challenges. Such altered memory states drive monocyte dysregulation during sepsis, promoting pathogenic behavior characterized by pro-inflammatory, immunosuppressive gene expression and emergency hematopoiesis. Epigenetic changes, notably via histone modifications, have been shown to underlie innate immune memory, but the contribution of DNA methylation remains poorly understood. more...