GSM7893427[Accession] - GEO DataSets

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Items: 4

Select item 2002475931.

Different doses of androgens induce the expression of distinct gene expression programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
100 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE247593

ID:: 200247593

PubMed Full text in PMC Similar studies

Select item 2002475912.

Different doses of androgens induce the expression of distinct gene expression programs (ATAC-Seq)

(Submitter supplied) Most prostate cancers express the androgen receptor (AR), and tumor growth and progression are facilitated by exceptionally low levels of systemic or intratumorally produced androgens. Paradoxically, high dose androgens have also shown considerable efficacy in the treatment of patients with late-stage metastatic PCa. In probing the mechanisms that enable cells to recognize and respond to different levels of the same hormone, it was determined that low levels of androgens, functioning through an AR monomer, facilitates a non-genomic activation of the mTOR signaling pathway to drive proliferation. more...