GEO DataSets

(Submitter supplied) Differential gene expression assessed in siTNF-OMe-P treated animals showed significant correlation between improved colon integrity and clinical parameters of colitis with reduced TLR activation, tissue regeneration and reduced pro-inflammatory cytokines, as compared to all treatment groups. This data shows the changes in gene expression profile associated with effective silencing of TNFa by a chemically-modified siRNA in the colon of colitic mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4371

Platform:

GPL6246

36 Samples

Download data: CEL

Analysis of distal colon from dextran sulfate sodium-treated C57BL/6 females after administration of chemically modified siRNA against TNFα, a proinflammatory cytokine involved in inflammatory bowel disease (IBD). Results provide insight into functionally enhanced siRNA targeting of TNFα in IBD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 5 protocol sets

Platform:

GPL6246

Series:

GSE31906

36 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2502 Series

28 Related Platforms

30399 Samples

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