GSM7946794[Accession] - GEO DataSets

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Items: 4

Select item 2002190831.

G-quadruplex folding in Xist RNA antagonizes PRC2 activity for step-wise regulation of X-chromosome inactivation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL24247
36 Samples

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Series

Accession:: GSE219083

ID:: 200219083

PubMed Similar studies

Select item 2002190802.

Epigenetic regulation by dynamic RNA G-quadruplex folding and unfolding (CHART-Seq)

(Submitter supplied) Whether RNA G-quadruplexes (rG4) form extensively in vivo and what roles they play remain actively debated. Among their proposed functions is recognition of Polycomb repressive complex 2 (PRC2), but how the interaction results in epigenetic regulation is not understood. Here we demonstrate that rG4s form dynamically during ES cell differentiation and require ATRX’s helicase function to unwind competing secondary structures. more...