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Items: 4

1.

G-quadruplex folding in Xist RNA antagonizes PRC2 activity for step-wise regulation of X-chromosome inactivation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL24247
36 Samples
Download data: BW, CSV
Series
Accession:
GSE219083
ID:
200219083
2.

Epigenetic regulation by dynamic RNA G-quadruplex folding and unfolding (ChIP-Seq)

(Submitter supplied) Whether RNA G-quadruplexes (rG4) form extensively in vivo and what roles they play remain actively debated. Among their proposed functions is recognition of Polycomb repressive complex 2 (PRC2), but how the interaction results in epigenetic regulation is not understood. Here we demonstrate that rG4s form dynamically during ES cell differentiation and require ATRX’s helicase function to unwind competing secondary structures. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL24247
12 Samples
Download data: BW
Series
Accession:
GSE219082
ID:
200219082
3.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
4.

WT(3rG4) K27me3 rep1 input

Organism:
Mus musculus
Source name:
Day 7 differentiated mouse embryonic stem cells
Platform:
GPL24247
Series:
GSE219082 GSE219083
Download data
Sample
Accession:
GSM7946839
ID:
307946839
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Supplemental Content

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