GSM8046350[Accession] - GEO DataSets

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Items: 4

Select item 2002545711.

APP and its intracellular domain modulate Alzheimer’s disease risk gene networks in transgenic APPsw and PSEN1M146I porcine models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Sus scrofa

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26285
41 Samples

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Accession:: GSE254571

ID:: 200254571

Select item 2002545702.

APP and its intracellular domain modulate Alzheimer’s disease risk gene networks in transgenic APPsw and PSEN1M146I porcine models [fibroblasts]

(Submitter supplied) Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most frequent cause of dementia. The disease has a substantial genetic component comprising both highly penetrant familial mutations (APP, PSEN1 and PSEN2) and sporadic cases with complex genetic etiology. Mutations in APP and PSEN1/2 alter the proteolytic processing of APP to its metabolites, including Ab and APP Intracellular Domain (AICD). more...