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Items: 3

1.

Putting the STING back into BH3-mimetic drugs for TP53 mutant blood cancers

(Submitter supplied) TP53-mutant blood cancers remain a major clinical challenge. BH3-mimetic drugs inhibit BCL-2 pro-survival proteins to promote cancer cell apoptosis. Despite acting downstream of TP53, functional TP53 is required for maximal cancer cell killing by BH3-mimetics through an unknown mechanism. Here, we report TP53 can be activated following BH3-mimetic induced mitochondrial outer membrane permeabilization, which leads to induction of BH3-only proteins, thereby potentiating the pro-apoptotic signal. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30172
28 Samples
Download data: TXT
Series
Accession:
GSE261373
ID:
200261373

2.

NextSeq 2000 (Mus musculus)

Organism:
Mus musculus
930 Series
15968 Samples
Download data
Platform
Accession:
GPL30172
ID:
100030172

3.

AF47A_hBim_S6

Organism:
Mus musculus
Source name:
Eu-Myc mouse lymphoma
Platform:
GPL30172
Series:
GSE261373
Download data
Sample
Accession:
GSM8141592
ID:
308141592

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db=gds|term=GSM8141592[Accession]|query=1|qty=2|blobid=MCID_67089985475a635e858c143f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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