GSM8145251[Accession] - GEO DataSets

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Items: 4

Select item 2002307161.

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL24676 GPL20301
66 Samples

Download data: BW, TXT

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Accession:: GSE230716

ID:: 200230716

Select item 2002307152.

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons [WGBS]

(Submitter supplied) Mutations in the methyl-DNA-binding protein MECP2 cause the neurodevelopmental disorder Rett syndrome (RTT). How MECP2 contributes to transcriptional regulation in normal and disease states is unresolved; it has been reported to be an activator and a repressor. We describe here the first integrated CUT&Tag, transcriptome, and proteome analyses using human neurons with wild-type and mutant MECP2 molecules. more...