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Items: 3

1.

Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs

(Submitter supplied) Translating genetic findings for neurodevelopmental and psychiatric disorders (NPD) into actionable disease biology would benefit from large-scale and unbiased functional studies of NPD genes. Leveraging the cytosine base editing (CBE) system, here we developed a pipeline for clonal loss-of-function (LoF) allele mutagenesis in human induced pluripotent stem cells (hiPSCs) by introducing premature stop-codons (iSTOP) that lead to mRNA nonsense-mediated-decay (NMD) or protein truncation. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL34281
69 Samples
Download data: TSV
Series
Accession:
GSE262442
ID:
200262442

2.

Illumina NovaSeq X (Homo sapiens)

Organism:
Homo sapiens
61 Series
914 Samples
Download data
Platform
Accession:
GPL34281
ID:
100034281

3.

V4615

Organism:
Homo sapiens
Source name:
iPS Cells
Platform:
GPL34281
Series:
GSE262442
Download data
Sample
Accession:
GSM8169872
ID:
308169872

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db=gds|term=GSM8169872[Accession]|query=10|qty=2|blobid=MCID_67393238c743ad79f733b6f7|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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