GSM8306589[Accession] - GEO DataSets

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Items: 4

Select item 2002691281.

Notch induces transcription by stimulating release of paused RNA Pol II without increasing chromatin accessibility.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing

Platform:: GPL24676
87 Samples

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Series

Accession:: GSE269128

ID:: 200269128

Select item 2002691162.

Notch induces transcription by stimulating release of paused RNA Pol II without increasing chromatin accessibility [TT-seq]

(Submitter supplied) Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that influences a wide range of cell fate decisions by regulating gene activity. However, despite years of study, how Notch induces the transcription of its target genes remains unclear. Here, we comprehensively examined the response to human Notch1 across a time course of activation, using genomic assays of nascent RNA and chromatin accessibility. more...