GEO DataSets

(Submitter supplied) Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number differences (CNDs) of conserved sequences across 3 primate species and examined their potential effects on gene expression profiles. Samples with copy number different genes had significantly different expression than samples with neutral copy number. Genes encoding regulatory molecules differed in copy number and were associated with significant expression differences. Additionally, we identified 127 CNDs which were processed pseudogenes and some of which were expressed. Furthermore, there were copy number different regulatory regions such as ultraconserved elements and long intergenic noncoding RNAs with the potential to affect expression. We postulate that CNDs of these conserved sequences fine-tune developmental pathways by altering the levels of RNA.

Organism:

Macaca mulatta; Homo sapiens; Pan troglodytes; Pongo abelii; Gorilla beringei

Type:

Genome variation profiling by genome tiling array

Platform:

GPL14930

17 Samples

Download data: TXT

(Submitter supplied) Agilent catalog probes for human (hg18) were downloaded from eArray and aligned against the chimpanzee (panTro2) and rhesus macaque(rheMac2) reference genomes using BLAT. Those probes that had at least 100% match to both reference genomes were similarity filtered based on the human reference genome (i.e. probes with only 1 perfect hit to hg18 were considered for the array). This array should not be considered as a genome-wide, unbiased copy number difference copy number discovery array. more...

Organism:

Homo sapiens

1 Series

17 Samples

Download data