GSM85459[Accession] - GEO DataSets

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Items: 3

Select item 2000036991.

DNA-Methyltransferases (DNMT) knockouts

(Submitter supplied) Alterations in DNA-methylation are a hallmark of human tumor cells. DNMT1 is expressed in three different splice variants and exhibits considerable preference for hemimethylated DNA and is therefore referred to as the maintenance methylase. DNMT3b is generally considered to be responsible for de novo methylation during embryonic development and probably also during tumor development. Recent studies using somatic knock-out of DNA-methyltransferases have shown a reduction in overall methylation and a re-expression of tumor suppressor genes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3050
14 Samples

Download data: GPR

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Accession:: GSE3699

ID:: 200003699

Select item 1000030502.

Human Unigene3.1 cDNA Array 37.5K v1.0

(Submitter supplied) The human Unigene3.1 cDNA Array represents 37530 cDNA clones provided by "Deutsches Ressourcenzentrum fuer Genomforschung (RZPD)" Protocol: The microarrays carried 37,530 human cDNA clones (human UniGene Set RZPD3.1, German Resource Center for Genome Research, Berlin, Germany). DNA fragments were amplified by PCR and spotted on epoxysilane glass slides (Quantifoil, Jena, Germany) using the VersArray ChipWriter Pro System (Biorad, Munich, Germany) and SMP3 pins (Telechem, Sunnyvale, CA, USA). more...