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Items: 4

1.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity [MRE-seq]

(Submitter supplied) The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed in mouse embryonic stem cells (mESCs) and has been implicated in mESC maintenance. Here we demonstrate that, unlike genetic deletion, RNAi-mediated depletion of Tet1 in mESCs led to a significant reduction in 5hmC and loss of mESC identity. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL9250
4 Samples
Download data: BED, WIG
Series
Accession:
GSE34887
ID:
200034887

SRA Run Selector

2.

Acute depletion of Tet1-dependent 5-hydroxymethylcytosine levels impairs LIF/Stat3 signaling and results in loss of embryonic stem cell identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Methylation profiling by high throughput sequencing
Platforms:
GPL14661 GPL9250
12 Samples
Download data: BED, CEL, WIG
Series
Accession:
GSE34267
ID:
200034267

Analyze with GEO2R

3.

Illumina Genome Analyzer II (Mus musculus)

Organism:
Mus musculus
802 Series
5962 Samples
Download data
Platform
Accession:
GPL9250
ID:
100009250

4.

Control ES cells 96hr, untreated DNA-Seq

Organism:
Mus musculus
Source name:
Control ES_96hr_untreated DNA-Seq
Platform:
GPL9250
Series:
GSE34267 GSE34887
Download data: BED, WIG
Sample
Accession:
GSM857135
ID:
300857135

SRA Run Selector

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db=gds|term=GSM857135[Accession]|query=2|qty=2|blobid=MCID_673bc217e6b130283a1a8d74|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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