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Items: 4

1.

Expression data from a reversible dasatinib-resistant state in long-term dasatinib-treated c-KIT-mutated Kasumi-1 cell line

(Submitter supplied) Long-term treatment of Kasumi-1 cells at clinically attained doses of dasatinib led to decreased drug-sensitivity by means of IC50 values (relative to treatment-naive cells). Changes were paralled by profound alterations in c-KIT expression and cell signaling signatures. Upon brief discontinuation of dasatinib treatment, these alterations reversed and drug sensitivity was restored. We used gene expression profiling to examine reversal of dasatinib-resistance at the molecular/expression level.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5600
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE39073
ID:
200039073

PubMed Similar studies Analyze with GEO2R

2.
Full record GDS5600

Acute myeloid leukemia cell line Kasumi-1 response to dasatinib treatment and withdrawal

Analysis of dasatinib-sensitive, KITmut t(8;21) AML cell line Kasumi-1 treated with dasatinib for 12 wks giving rise to R48 cells. After 1 wk of dasatinib cessation, R48 cells give rise to PR48 cells. Results provide insight into molecular effects of long-term dasatinib treatment on t(8;21) AML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 3 cell line, 3 protocol sets
Platform:
GPL6244
Series:
GSE39073
9 Samples
Download data: CEL
DataSet
Accession:
GDS5600
ID:
5600

PubMed Similar studies GEO Profiles Analyze DataSet

3.

[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 18, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site
Organism:
Homo sapiens
136 DataSets
1879 Series
27 Related Platforms
38399 Samples
Download data
Platform
Accession:
GPL6244
ID:
100006244

4.

K cells, technical replicate 2

Organism:
Homo sapiens
Source name:
Kasumi-1 cells, left untreated
Platform:
GPL6244
Series:
GSE39073
Dataset:
GDS5600
Download data: CEL
Sample
Accession:
GSM955190
ID:
300955190

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