GEO DataSets

(Submitter supplied) Microarrray experiments were performed in order to identify genes whose expression is altered under hypoxic conditions and to determine whether these changes are dependant on the p53 and HIF tanscription factors. In order to determine HIF dependance, isogenic RCC4 cell lines were used that were either wildtype of null for vhl, the gene responsible for degrading HIF under normoxic conditions. In order to determine p53 dependance, isogenic HCT116 and H1299 cell lines that were wildtype or null for p53 were used. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1772

Platform:

GPL3423

30 Samples

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Analysis of cell lines lacking VHL or p53 following exposure to hypoxia. VHL is the gene responsible for degrading transcription factor HIF-1. p53 null mutants examined to identify genes whose expression under hypoxia depends on p53. Results identify genes regulated by HIF-1.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 cell line, 4 genotype/variation, 4 stress, 8 time sets

Platform:

GPL3423

Series:

GSE4186

30 Samples

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(Submitter supplied) see manufacturer's website

Organism:

Homo sapiens

1 DataSet

1 Series

30 Samples

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