GSM993414[Accession] - GEO DataSets

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Items: 4

Select item 2000404171.

Acute and long-term effects of mutant p53 in vivo

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
38 Samples

Download data: CEL

Series

Accession:: GSE40417

ID:: 200040417

Select item 2000404142.

Acute and long-term effects of mutant p53 in vivo [Thymus]

(Submitter supplied) The specific roles of mutant p53’s dominant-negative (DN) or gain-of-function (GOF) properties in regulating acute response and long-term tumorigenesis is unclear. Using “knock-in” mouse strains expressing varying R246S mutant levels, we show that DN effect on transactivation is universally observed after acute p53 activation whereas the effect on cellular outcome is cell-type specific. Reducing mutant p53 levels abrogated the DN effect. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6096
10 Samples

Download data: CEL

Series

Accession:: GSE40414

ID:: 200040414

Select item 1000060963.

[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [transcript (gene) version]

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html #%create_date=Wed Mar 11 17:52:08 2009 PDT #%chip_type=MoEx-1_0-st-v1 #%lib_set_name=MoEx-1_0-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm9 #%genome-version-ucsc=mm9 #%genome-version-ncbi=37 #%genome-version-create_date=2007-07 #%netaffx-annotation-date=2009-03-16 #%netaffx-annotation-netaffx-build=28 Protocol: See manufacturer's web site