GEO DataSets

(Submitter supplied) Background: DNA methylation influences transcriptional regulation, and therefore cellular phenotype, across all domains of life. The regulatory role of DNA methylation and other epigenetic marks also extends to virulence; both orphan methyltransferases and those from restriction modification systems (RMSs) have been co-opted to regulate virulence in many bacteria. However, functional characterisation of DNA methylation mediated by archetypal Type I RMSs remains limited. more...

Organism:

Escherichia coli CFT073; Escherichia coli str. K-12 substr. MG1655; Escherichia coli UTI89

Type:

Expression profiling by high throughput sequencing

7 related Platforms

64 Samples

Download data: XLSX

(Submitter supplied) Specific recognition and bacterial adhesion to host cells by uropathogenic E. coli (UPEC) are the first steps towards infection of epithelial tissue of the human urogenital system. Therefore, targeting of UPEC virulence factors, relevant for adhesion, is a promising approach for prevention of recurrent urinary tract infections (UTI). A fully characterized plant-derived aqueous extract from the leaves of Orthosiphon stamineus (OWE), a plant traditionally used in clinical practice in Europe and Asia for UTI, has been shown to exert strong antiadhesive effects under in vitro and in vivo conditions. more...

Organism:

Escherichia coli UTI89

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26680

2 Samples

Download data: XLSX

(Submitter supplied) The expression levels of uropathogenic E. coli (UPEC) UTI89 cells in YESCA broth with and without 4% dimehtyl sulfoxide (DMSO) and 2% ethanol (EtOH) were studied.

Organism:

Escherichia coli UTI89; Escherichia coli

Type:

Expression profiling by array

Platform:

GPL3154

4 Samples

Download data: CEL, CHP

(Submitter supplied) While in transit within and between hosts, uropathogenic E. coli (UPEC) encounter multiple stresses, including substantial levels of nitric oxide and reactive nitrogen intermediates. Strains of UPEC become conditioned to high concentrations of acidified sodium nitrite (ASN), a model system used to generate nitrosative stress. We used microarrays to define the expression profile of UPEC that have been conditioned for growth in ASN.

Organism:

Escherichia coli; Escherichia coli UTI89

Type:

Expression profiling by array

Platform:

GPL3154

4 Samples

Download data: CEL