GEO DataSets

(Submitter supplied) DNA methylation is an epigenetic modification involved in regulatory processes such as cell differentiation during development, X-chromosome inactivation, genomic imprinting and susceptibility to complex diseases. These changes can be inherited through generations and likely have played an important role during human evolution. We performed a comparative analysis of CpG methylation patterns between humans and all great apes (chimpanzee, bonobo, gorilla and orangutan) on a total of 32 individuals.Our analysis identified ~1,000 genes with significantly altered methylation patterns among the great apes, including ~200 with a methylation pattern unique to humans. more...

Organism:

Pongo pygmaeus; Homo sapiens; Pan troglodytes verus; Pan paniscus; Pan troglodytes schweinfurthii; Pan troglodytes troglodytes; Gorilla gorilla gorilla; Pongo abelii; Gorilla beringei graueri

Type:

Methylation profiling by array

Platform:

GPL13534

32 Samples

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