GEO DataSets

(Submitter supplied) African green monkeys (AGMs) are a natural host for a lentivirus related to human immunodeficiency virus, simian immunodeficiency virus. SIV-infected AGM rarely progress to AIDS despite robust viral replication. Though multiple mechanisms are involved, a primary component is their ability to downregulate CD4 expression on mature helper CD4+ T cells, rendering these cells resistant to infection by SIV. more...

Organism:

Chlorocebus pygerythrus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL31285 GPL28888

50 Samples

Download data: BW, NARROWPEAK

(Submitter supplied) The Coronaviridae are a family of positive- strand RNA viruses that includes SARS-CoV-2, the etiologic agent of the COVID-19 pandemic. Bearing the largest single stranded RNA genome in nature, coronaviruses are critically dependent on long-distance RNA-RNA interactions to regulate the viral transcription and replication pathways. Here we experimentally mapped the in vivo long-range RNA interactome of the full-length SARS-CoV-2 genome and the subgenomic mRNAs. more...

Organism:

Homo sapiens; Chlorocebus pygerythrus

Type:

Other

Platforms:

GPL24676 GPL28888

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Chlorocebus pygerythrus; Erythrocebus patas; Macaca mulatta

Type:

Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms

60 Samples

Download data: COV, TXT

(Submitter supplied) African green monkeys (AGMs) are natural hosts of Simian immunodeficiency virus (SIV) that post-thymically down-regulate CD4 to maintain a large population of CD4-CD8aa+ virus-resistant cells with T-helper functionality. AGMs can become aviremic and seemingly cured of SIV by down-regulating CD4 in all CD4+ T cells in vivo. To understand the mechanisms of this process we performed genome-wide transcriptional analysis on T cells induced to down-regulate CD4 in vitro from AGMs and closely-related Patas monkeys, and T cells that maintain CD4 expression from rhesus macaques. more...

Organism:

Erythrocebus patas; Macaca mulatta; Chlorocebus pygerythrus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL28631 GPL28632 GPL19129

48 Samples

Download data: TXT

(Submitter supplied) African green monkeys (AGMs) are natural hosts of Simian immunodeficiency virus (SIV) that post-thymically down-regulate CD4 to maintain a large population of CD4-CD8aa+ virus-resistant cells with T-helper functionality. AGMs can become aviremic and seemingly cured of SIV by down-regulating CD4 in all CD4+ T cells in vivo. To understand the mechanisms of this process we performed genome-wide transcriptional analysis on T cells induced to down-regulate CD4 in vitro from AGMs and closely-related Patas monkeys, and T cells that maintain CD4 expression from rhesus macaques. more...

Organism:

Chlorocebus pygerythrus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL28617

12 Samples

Download data: COV