GEO DataSet Links for BioProject (Select 100699) - GEO DataSets

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Items: 2

Select item 2000079551.

Transcriptional response of rat cerebrocortical tissue following acute exposure to permethrin or deltamethrin.

(Submitter supplied) Pyrethroids are neurotoxicants that disrupt nervous system function by interacting with a variety of membrane bound ion channels on neuronal plasma membranes. This study is designed to investigate the transcriptional events downstream of pyrethroid-induced disruption of nervous system excitability. Adult, male Long-Evans rats were orally dosed in vivo with a single dose of either permethrin (1, 10, or 100 mg/kg) or deltamethrin (0.3, 1, 3 mg/kg) at levels that produce only modest behaviroal effects in the whole animal (Wolansky et al. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2998
Platform:: GPL1355
60 Samples

Download data: CEL, CHP

Series

Accession:: GSE7955

ID:: 200007955

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 29982.

Deltamethrin and permethrin effect on the frontal cerebral cortex: dose response

Analysis of brain frontal cerebral cortices of animals treated with various doses of deltamethrin or permethrin, which are neurotoxic pyrethroids used as insecticides. Results provide insight into molecular mechanisms underlying pyrethroid-induced disruption of nervous system excitability.