Repurposed nuclear speckle and mitosis components induce CTCF clustering to sustain the senescence splicing program [eCLIP] - - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Result Filters

Summary

Format

Summary
Summary (text)
Unique Identifier List

Send to:

Choose Destination

File
Clipboard
Collections

Links from BioProject

Repurposed nuclear speckle and mitosis components induce CTCF clustering to sustain the senescence splicing program [eCLIP]

(Submitter supplied) Senescence —the end-point of the replicative life span of normal cells— is characterized by a complex sequence of molecular and biochemical events. One of these is the dramatic reorganization of CTCF into large senescence-induced CTCF clusters (SICCs). However, the molecular determinants, genomic consequences, and functional purpose of SICCs remained unknown. Here, we combine super-resolution imaging, 3D genomics, and functional assays with computational modelling to address all aspects of SICC emergence. more...