GEO DataSet Links for BioProject (Select 125723) - GEO DataSets

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Items: 2

Select item 2000202111.

LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells

(Submitter supplied) [original title] LMP-420: a novel purine nucleoside analogue with potent cytotoxic effects for chronic lymphocytic leukemia cells and minimal toxicity for normal hematopoietic cells. LMP-420 induces cytotoxicity and apoptosis to CLL cells in vitro without any negative effects to normal immune cells. This gene expression experiment compares CLL cells treated with LMP-420 versus media alone to investigate the mechanism of action of LMP-420.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4202
Platform:: GPL570
26 Samples

Download data: CEL

Series

Accession:: GSE20211

ID:: 200020211

Select item 42022.

Primary chronic lymphocytic leukemia cell response to purine nucleoside analog LMP-420

Analysis of chronic lymphocytic leukemia (CLL) patient cells cultured with LMP-420 (2 uM) for 24 hr. LMP-420 is an anti-inflammatory agent that induces CLL cell apoptosis in vitro without impairing normal immune cells. Results provide insight into the mechanism of action of LMP-420 in CLL.