GEO DataSet Links for BioProject (Select 135127) - GEO DataSets

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Items: 2

Select item 2000262981.

Under conditions of hormonal adjuvant treatment the estrogen receptor apoprotein supports breast cancer cell cycling through the retinoic acid receptor α1 apoprotein

(Submitter supplied) Under conditions of hormonal adjuvant treatment the estrogen receptor apoprotein supports breast cancer cell cycling through the retinoic acid receptor α1 apoprotein. Basal proliferation persisted in estrogen-sensitive breast cancer cells grown in hormone depleted conditioned media without or with 4-hydroxytamoxifen (OH-Tam). Downregulating ER using siRNA inhibited basal proliferation by promoting cell cycle arrest. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4065
Platform:: GPL570
12 Samples

Download data: CEL

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Accession:: GSE26298

ID:: 200026298

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40652.

Effect of estrogen receptor- or retinoic acid receptor-knockdown on estrogen-sensitive MCF7 breast cancer cells

Analysis of MCF7 cells transfected with control siRNA, estrogen receptor α (ER) siRNA or retinoic acid receptor α (RARα) siRNA. Basal proliferation of MCF7 cells was diminished by knocking down ER or RARα. Results provided insight into the molecular basis of basal proliferation.