GEO DataSets

(Submitter supplied) Dilated cardiomyopathy (DCM) is the leading cause of heart failure and transplantation worldwide. We used iPSCs to model this disease and compared gene expression change before and after gene therapy of cardiomyocytes derived from DCM-specific iPSCs. We used microarrays to detail the global gene expression of patient specific iPSCs, iPSC-derived cardiomyocytes and its response to gene therapy.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS4312 GDS4435

Platform:

GPL6244

17 Samples

Download data: CEL

Analysis of DCM iPSC-derived cardiomyocytes treated with sarcoplasmic reticulum Ca2+ adenosine triphosphatase (Serca2a). Serca2a treatment improved the function of these cardiomyocytes. Results provide insight into the molecular basis of Serca2a-mediated repair of DCM iPSC-derived cardiomyocytes.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 cell type, 2 protocol sets

Platform:

GPL6244

Series:

GSE35108

8 Samples

Download data: CEL

Analysis of iPSCs derived from skin fibroblasts of Dilated Cardiomyopathy (DCM) family members carrying point mutation R173W in the sarcomeric protein cardiac troponin T (TNNT2) gene. Results provide insight into the molecular mechanisms underlying familial dilated cardiomyopathy.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 cell type, 2 genotype/variation, 9 individual sets

Platform:

GPL6244

Series:

GSE35108

9 Samples

Download data: CEL