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Items: 2

1.

Defining key signaling nodes and therapeutic biomarkers in NF1-mutant cancers

(Submitter supplied) The NF1 tumor suppressor encodes a RAS GTPase-Activating Protein (RasGAP). Accordingly, deregulated RAS signaling underlies the pathogenesis of NF1-mutant cancers. However, while various RAS effector pathways have been shown to function in these tumors, it is currently unclear which specific proteins within these broad signaling pathways represent optimal therapeutic targets. Here we identify mTORC1 as the key PI3K pathway component in NF1-mutant nervous system malignancies and conversely show that mTORC2 and AKT are dispensable. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5419
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE57141
ID:
200057141
2.
Full record GDS5419

MEK inhibitor PD-0325901 and rapamycin combined treatment effect on malignant peripheral nerve sheath tumor model

Analysis of malignant peripheral nerve sheath tumors (MPNST) from NPcis animals (carrying Nf1 and p53 mutations) treated with rapamycin, MEK inhibitor PD-0325901, or the combination of rapamycin and PD-0325901. Results provide insight into the molecular mechanisms underlying MPNST pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 protocol sets
Platform:
GPL6246
Series:
GSE57141
8 Samples
Download data: CEL

Supplemental Content

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