GEO DataSet Links for BioProject (Select 272720) - GEO DataSets

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Items: 2

Select item 2000650181.

The epithelial cell transcriptome after alpha-toxin treatment

(Submitter supplied) Responsiveness of cells to alpha-toxin (Hla) from Staphylococcus aureus appears to occur in a cell-type dependent manner. Here, we compare two human bronchial epithelial cell lines, i.e. Hla-susceptible 16HBE14o- and Hla-resistant S9 cells, by a quantitative multi-omics strategy for a better understanding of Hla-induced cellular programs. Phosphoproteomics revealed a substantial impact on phosphorylation-dependent signaling in both cell models and highlights alterations in signaling pathways associated with cell-cell and cell-matrix contacts as well as the actin cytoskeleton as key features of early rHla-induced effects. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5812
Platform:: GPL6244
8 Samples

Download data: CEL

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Accession:: GSE65018

ID:: 200065018

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 58122.

Staphylococcal alpha-toxin effect on airway epithelial cells

Analysis of bronchial epithelial cell lines 16HBE14o- (Hla-susceptible) and S9 (Hla-resistant) treated with S. aureus recombinant alpha-toxin (rHla) for 2 hrs. Results provide insight into molecular mechanisms underlying cell type-specific responses of airway epithelial cells to alpha-toxin.