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Set1-mediated histone H3K4 methylation is conserved and required for azole induction of ergosterol biosynthesis genes and antifungal drug resistance in Candida glabrata

(Submitter supplied) Fungal infections are a major health concern because of limited antifungal drugs and development of drug resistance. Candida can develop azole drug resistance by overexpression of drug efflux pumps or mutating ERG11, the target of azoles. However, the role of epigenetic histone modifications in azole-induced gene expression and drug resistance is poorly understood in Candida glabrata. In this study, we show that Set1 mediates histone H3K4 methylation in C. more...
Organism:
Nakaseomyces glabratus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30061
12 Samples
Download data: XLSX
Series
Accession:
GSE209637
ID:
200209637

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