GEO DataSets

Analysis of pancreas of diabetic animals after treatment with sodium tungstate, which induces beta cell mass growth. Diabetes induced by streptozotocin. Results provide insight into the mechanisms underlying the regenerative effect of sodium tungstate on the pancreas of models of diabetes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 2 disease state sets

Platform:

GPL341

Series:

GSE2470

12 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Background and Aims: It is well demonstrated that in the beta cell population of the pancreas there is a dynamic turnover, which results from the net balance of several processes; beta cell replication, apoptosis and neogenesis. These processes have been studied in partial pancreatectomy and glucagon-like peptide 1 treated animals, where an increase in pancreas regeneration has been observed. Similarly, sodium tungstate, which decreases hyperglycemia in several animal models of diabetes, promotes a rise in the beta cell mass of nSTZ and STZ animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1883

Platform:

GPL341

12 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) Relative beta cell deficit and increased beta cell apoptosis are hallmarks of type 2 diabetes (T2D). The Insulin/Insulin Growth Factor (Igf) signaling pathway is an established regulator of beta cell survival and is found downregulated in human T2D islets. The Insulin Receptor Substrate 2 (Irs2) plays a central role in the coordination of this pathway in beta cells. Thus, Irs2 knockout mice (Irs2 -/-) exhibit increased beta cell apoptosis that leads to a progressive decline of beta cell mass and hyperglycaemia. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5380

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of pancreatic islets from insulin receptor substrate 2 (Irs2) knockouts treated with anti-diabetic compound sodium tungstate for 21 days. Tungstate normalizes glucose tolerance in the Irs2 -/- animals. Results provide insight into the molecular effects of tungstate on pancreatic β-cells.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE43620

8 Samples

Download data: CEL

(Submitter supplied) AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and therefore may be involved in regulation of beta cell homeostasis. The aim of this study was to investigate the involvement of RKIP1 in the control of beta cell mass and function. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4331

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of pancreas from Raf kinase inhibitor 1 (Rkip1) knockouts. Rkip1-/- mice exhibit a larger pancreas and increased beta cell mass and pancreatic insulin content. Results provide insight into the role of Rkip1 in regulation of pancreatic beta cell function and proliferation.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE31150

6 Samples

Download data: CEL

(Submitter supplied) INTRODUCTION: Targeting β-cell failure could prevent, delay or even partially reverse Type 2 Diabetes. However, development of such drugs is limited as the molecular pathogenesis is complex and incompletely understood. Further, while β-cell failure can be modelled experimentally only some of the molecular changes will be pathogenic. Therefore, we used a novel approach to identify molecular pathways that are not only changed in a diabetes-like state but are reversible and can be targeted by drugs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18694

59 Samples

Download data: XLSX