GEO DataSets

(Submitter supplied) The aim of this project is to identify distinct temporal patterns of RNA expression in the skeletal muscle of rats following a bolus dose of the corticosteroid methylprednisolone. 51 RG_U34A chips were used over 17 time points. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS256

Platform:

GPL85

51 Samples

Download data: CEL

(Submitter supplied) Synthetic glucocorticoids are used therapeutically for a variety of conditions. Both the efficacy and toxicity of corticosteroids arise from their pharmacologically exaggerated effects on target and non-target tissues. For example, beneficial effects deriving from inhibition of the immune system are accompanied by toxic side effects that include hyperglycemia, dyslipidaemia, muscle wasting, fatty liver, and an increased risk of atherosclerosis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2688

Platform:

GPL341

44 Samples

Download data: CEL

Analysis of skeletal muscles of adrenalectomized animals given methylprednisolone (MPL) at a constant rate of infusion for up to 7 days. Results compared to a time series experiment using a single dose of MPL. Results provide insight into the identity of genes regulated by MPL in both regimens.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 11 time sets

Platform:

GPL341

Series:

GSE5101

44 Samples

Download data: CEL

Temporal analysis of skeletal muscle response to corticosteroid methylprednisolone. Wistar rats injected with methylprednisolone and skeletal muscle analyzed at various time points up to 72 hours.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 17 time sets

Platform:

GPL85

Series:

GSE490

51 Samples

Download data: CEL

(Submitter supplied) Summary: To identify distinct temporal patterns of mRNA expression in the kidney of rats following a bolus dose of the corticosteroid methylprednisolone. Hypothesis: That prednisone pharmacodynamics can be derived from expression profiling data. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS964 GDS965

Platforms:

GPL341 GPL85

63 Samples

Download data: CEL

Expression profiling of kidneys from animals treated with methylprednisolone. Kidneys examined at various time points up to 6 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL85

Series:

GSE1721

10 Samples

Download data: CEL

Expression profiling of kidneys from animals treated with methylprednisolone. Kidneys examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 17 time sets

Platform:

GPL341

Series:

GSE1721

53 Samples

Download data: CEL

(Submitter supplied) Summary: The liver is the major site of gluconeogenesis, fat processing and distribution, as well as drug and xenobiotic metabolism. Altered gene expression in the liver is centrally invovled in both the immuosuppressive and the energetic actions of corticosteroids. Hypothesis: That pharmacodynamics can be derived from expression profiling data. Specific Aim: The aim of this project is to identify distinct temporal patters of RNA expression in the liver of rats following a bolus dose of the corticosteroid methylprednisolone. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS253 GDS972

Platforms:

GPL341 GPL85

91 Samples

Download data: CEL

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 168 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 11 time sets

Platform:

GPL341

Series:

GSE487

44 Samples

Download data: CEL

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 17 time sets

Platform:

GPL85

Series:

GSE487

46 Samples

Download data: CEL

(Submitter supplied) In intact animals, time of drug administration may be an important factor influencing drug response. Our general goal seeks to incorporate circadian time into the study of corticosteroid regulated gene expression. This study is designed to examine fluctuations in gene expression in skeletal muscle within the 24 hour circadian cycle in normal animals. Circadian time is relevant to designing optimal corticosteroid dosing regimens. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3083

Platform:

GPL341

54 Samples

Download data: CEL

Analysis of gastrocnemius muscles of Wistar animals during a 24-hour period, from zeitgeber time (ZT) 0.25 to ZT 23.75. Results provide insight into baseline patterns of gene expression in normal skeletal muscle within the 24 hour circadian cycle.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 18 time sets

Platform:

GPL341

Series:

GSE8989

54 Samples

Download data: CEL

(Submitter supplied) Global transcript profiling to identify differentially expressed skeletal muscle genes in insulin resistance, a major risk factor for Type II (non-insulin-dependent) diabetes mellitus. Compared gene expression profiles of skeletal muscle tissues from 18 insulin-sensitive versus 17 insulin-resistant equally obese, non-diabetic Pima Indians. Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS157 GDS158 GDS160 GDS161 GDS162

5 related Platforms

50 Samples

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(Submitter supplied) Muscle sample pool #5 from 2 insulin resistant subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

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(Submitter supplied) Muscle sample pool #4 from 3 insulin resistant subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) Muscle sample pool #3 from 4 insulin resistant subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) Muscle sample pool #2 from 4 insulin resistant subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) Muscle sample pool #1 from 4 insulin resistant subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) Muscle sample pool #5 from 4 insulin sensitive subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data

(Submitter supplied) Muscle sample pool #4 from 3 insulin sensitive subjects. Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

5 related Platforms

5 Samples

Download data