GEO DataSets

(Submitter supplied) Purpose of the study The encounter between Candida albicans and phagocytes (macrophages) is considered the initial step in the development of host immune defenses. The single utility of proteomic and genomic approaches to study host - pathogen interaction has been previously described in the literature (1, 2, 3); but up to now few studies have employed both techniques as complementary approaches. Because of the importance of the macrophages in the innate immune response against fungal infectious, we have investigated the transcriptional profiling and the differential protein expression (using a proteomic approach) of C. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL3727

4 Samples

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(Submitter supplied) Candidiasis is an infection caused by yeasts of the genus Candida that ranges in severity from debilitating mucosal infections to disseminated disease with high mortality rates. C. albicans is the most common cause of infection, but non-albicans species collectively represent a significant disease burden. Disseminated disease rarely affects immunocompetent individuals, largely due to the action of innate immune cells, including macrophages, in controlling infection. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

21 Samples

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(Submitter supplied) Pathogenic Candida fungi are a leading cause of opportunistic, hospital-associated bloodstream infections with high mortality rates, typically in immunocompromised patients. Several species, including C. albicans, the most prevalent cause of infection, belong to the monophyletic CUG clade of yeasts. Much is known about the interaction of C. albicans with innate immune cells, which are crucial for controlling infection. more...

Organism:

Candida albicans; Lodderomyces elongisporus; Candida parapsilosis; Clavispora lusitaniae; Candida tropicalis; Mus musculus; Candida dubliniensis

Type:

Expression profiling by high throughput sequencing

12 related Platforms

24 Samples

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(Submitter supplied) Purpose: The purpose of this study was to simulataneously examine the host and fungal pathogen transcriptional profiles of four distinct infection fates during macrophage and Candida albicans interactions Methods: Membrane stained (Deep Red),primary, bone marrow derived, murine macrophages and Candida albicans expressing GFP and mCherry were exposed to each other over a four hour time course. Samples were collected at 0, 1, 2 and 4 hours and sorted for four infection subpopulations: 1. more...

Organism:

Mus musculus; Candida albicans

Type:

Expression profiling by high throughput sequencing

4 related Platforms

306 Samples

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(Submitter supplied) Transcriptional profiling of Candida albicans that had been phagocytosed for 1, 2, or 4 hours by either bone marrow-derived mouse macrophaged (BMDM) or immortalized RAW264.7 cells Keywords: Time course

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL6822

24 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Danio rerio

Type:

Expression profiling by array

Platforms:

GPL14575 GPL6457

54 Samples

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(Submitter supplied) The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. The dynamic variations of significant genes expression profiles in C. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL6457

27 Samples

Download data: TXT

(Submitter supplied) The interaction between fungal pathogen and host during infection is a complex and dynamic process. To resolve this, we chose the zebrafish model organism as the host to study C. albicans infection via systems biology approach. Transcriptome microarray data and histological analysis of surviving fish were sampled at different post-infection time points. The dynamic variations of significant genes expression profiles in C. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL14575

27 Samples

Download data: TXT