GEO DataSets

(Submitter supplied) Gene expression information is useful in prioritizing candidate genes in linkage intervals. The data can also identify pathways involved in the pathophysiology of disease. We used microarrays to identify which genes are expressed in either intracranial arteries (control) or in intracranial aneurysms (case), and can therefore contribute to the disease phenotypes. We used microarrays to identify the pathway membership of expressed genes and the overrepresentation of pathways with expressed genes in the known linkage intervals for intracranial aneurysms. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2507 GPL570

10 Samples

Download data: CEL, TXT

(Submitter supplied) The biological mechanisms by which cerebral aneurysms emerge, enlarge and rupture are not totally understood. In the present study, we analyzed the genome-wide gene expression profile in human intracranial aneurysms using cDNA microarrays.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3903

Platform:

GPL570

6 Samples

Download data: CEL

Analysis of unruptured intracranial arterial aneurysm (IAA). IAA is a cerebrovascular disorder in which weakness in a cerebral artery wall causes localized dilation and possible rupture. Results provide insight into the molecular mechanisms underlying cerebral aneurysms.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL570

Series:

GSE26969

6 Samples

Download data: CEL

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

28 Samples

Download data: CEL

(Submitter supplied) The primary aim of the present study was to identify differences on the transcription level between ruptured and unruptured intracranial aneurysms as well as normal intracranial arteries in human. Keywords: Expression profiling by array

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

19 Samples

Download data: CEL

(Submitter supplied) We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian eye and to identify genetic variation relevant to human eye disease. Of >31,000 gene probes represented on an Affymetrix expression microarray, 18,976 exhibited sufficient signal for reliable analysis and at least 2-fold variation in expression among 120 F2 rats generated from an SR/JrHsd x SHRSP intercross. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

120 Samples

Download data: CEL

(Submitter supplied) The rupture of intracranial aneurysm (IA) causes subarachnoid hemorrhage associated with high morbidity and mortality. We compared gene expression profiles in aneurysmal domes between unruptured IAs (UIAs) and ruptured IAs (RIAs) to elucidate biological mechanisms predisposing to the rupture of IA. We determined gene expression levels of eight RIAs, five UIAs, and 10 superficial temporal arteries (STAs) with the Agilent microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5186

Platform:

GPL4133

23 Samples

Download data: TXT

Analysis of aneurysmal domes from ruptured intracranial aneurysms (RIAs). RIA causes subarachnoid hemorrhage associated with high morbidity and mortality. Results provides insight into molecular mechanisms that predispose to the rupture of IAs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 tissue sets

Platform:

GPL4133

Series:

GSE54083

23 Samples

Download data: TXT

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) In this study, we explored transcriptional differences in human neutrophils from patients with intracranial aneurysms and a demographic and comorbidity paired population of controls

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

32 Samples

Download data: TXT

(Submitter supplied) Background and Purpose: Genome-wide association studies significantly link intracranial aneurysm (IA) to single-nucleotide polymorphisms (SNPs) in six genomic loci. To gain insight into the relevance of these IA associated SNPs, we aimed to identify regulatory regions and analyze overall gene expression in the human circle of Willis (CoW), on which these aneurysms develop. Methods: We performed chromatin immunoprecipitation and sequencing for histone modifications H3K4me1 and H3K27ac to identify regulatory regions, including distal enhancers and active promoters, in post mortem specimens of the human CoW. more...

Organism:

Homo sapiens

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL11154

14 Samples

Download data: BED, TDF, TXT, XLS, XLSX

(Submitter supplied) Background and Purpose: We previously showed that intracranial aneurysm (IA)-associated single nucleotide polymorphisms (SNPs) are enriched in promoters and putative enhancers of the human circle of Willis (CoW), on which IAs develop, suggesting a role for such regulatory regions in IA. In this study we further investigated the role of these putative enhancers in the pathogenesis of IA by identifying the target genes of these enhancers and validating their regulatory activity. more...

Organism:

Homo sapiens

Type:

Other

Platforms:

GPL11154 GPL18573

47 Samples

Download data: WIG

(Submitter supplied) Array data for "Genetic Inheritance of Gene Expression in Human Cell Lines" Monks, et al., American Journal of Human Genetics (2004) Keywords = Genetics of Gene Expression Keywords = human Keywords = CEPH family Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1048

Platform:

GPL564

167 Samples

Download data

Expression profiling of lymphoblastoid cell lines from 15 CEPH/Utah families. Cell lines from 3 generations examined. Results provide insight into the heritability of gene expression traits in segregating human populations.

Organism:

Homo sapiens

Type:

Expression profiling by array, log ratio, 15 specimen sets

Platform:

GPL564

Series:

GSE1726

167 Samples

Download data